Menopause is defined as occurring 12 months after a woman’s last menstrual period and marks the end of menstrual cycles. In the U.S., the average age of menopause is 51. A rapid decline in estrogen with menopause may be associated with an increased risk of Alzheimer’s disease risk in women.The Women’s Health Initiative study by the National Institutes of Health (NIH) reported that menopausal hormone therapy started in women 65 or older increased the risk of dementia. In contrast, the multicenter Kronos Early Estrogen Prevention Study tested the hypothesis that healthy and younger women would respond to menopausal hormone therapy more favorably.The Mayo Clinic study used data from the Kronos study to determine the effects of menopausal hormone therapy shortly after menopause, during the critical window of rapid estrogen depletion — five to 36 months past menopause. Researchers investigated the brain amyloid deposition in 68 women ages 42 to 59 who participated in the Kronos trial during this critical window. The researchers used positron emission tomography, also known as a PET scan, to look for the brain amyloid deposits three years after the trial ended.Of the 68 women, 21 received estrogen via a skin patch, 17 received estrogen orally and 30 received a placebo. Amyloid deposition was lower in women who received the patch, compared to the placebo, and the effect was most apparent in women with the APOE e4 genotype. The oral treatment was not associated with lower amyloid deposition.The authors are seeking funding to perform amyloid PET imaging at eight more Kronos Early Estrogen Prevention study sites around the U.S.“If our results are confirmed in the larger group of women, this finding has the potential to change the concepts for preventive interventions that drive the Alzheimer’s disease field today,” Dr. Kantarci says. “It also may have a significant impact on women making the decision to use hormone therapy in the early postmenopausal years.” LinkedIn Pinterest Share on Twitter Share Email Share on Facebook Can estrogen preserve brain function and decrease the risk of Alzheimer’s disease when given early in menopause? Newly postmenopausal women who received estrogen via a skin patch had reduced beta-amyloid deposits, the sticky plaques found in the brains of people with Alzheimer’s disease, a Mayo Clinic study published this month in the Journal of Alzheimer’s Disease found. Ultimately, these deposits harm neurons, leading to cognitive problems.In the study, women with APOE e4 — one form of the most common gene associated with late-onset Alzheimer’s disease — had lower levels of amyloid deposits.“This study showed, for the first time, that the brain amyloid deposition — a hallmark of Alzheimer’s disease — is reduced in newly postmenopausal women who received 17beta-Estradiol patch form of hormone therapy,” says lead author Kejal Kantarci, M.D., a Mayo Clinic radiologist. “Women with APOE e4, who have a greater genetic risk for Alzheimer’s disease, particularly benefited from this therapy.”
DOE/NNSA News:The Department of Energy National Nuclear Security Administration’s Los Alamos Field Office (DOE/NNSA) has issued a categorical exclusion for the Tracking Aerosol Convection Interactions Experiment (TRACER) Project. The project is a collaboration between the DOE Office of Science, Los Alamos National Laboratory, Brookhaven National Laboratory, Southern Great Plains Atmospheric Radiation Measurement Research Facility, and the University of Houston. Temporary, mobile facilities will be deployed for one-year at three previously disturbed sites in Harris, Brazoria and Fort Bend counties in Texas. The mobile facilities will collect data required to improve computer model capabilities to predict worldwide climatic and atmospheric conditions. The categorical exclusion can be accessed online at https://www.energy.gov/nepa/downloads/cx-270533-tracking-aerosol-convection-interactions-experiment-tracer.
Construction on the roundabout Wednesday obliterates the intersection of Central and 4th Street. Photo by Ed Birnbaum
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Scorpio Tankers Inc. has taken delivery of a MR product tanker newbuilding, STI Opera, from Hyundai Mipo Dockyard Co., Ltd. of South Korea.The vessel will be time chartered-out for up to 120 days at approximately $19,000 per day.Scorpio Tankers Inc. currently owns 21 tankers (one LR2 tanker, four LR1 tankers, one Handymax tanker, 14 MR tankers, and one post-Panamax tanker) with an average age of 4.0 years, time charters-in 30 product tankers (nine LR2, four LR1, eight MR and nine Handymax tankers),The company has contracted 63 newbuilding vessels (30 MR, 12 LR2, and 14 Handymax ice class-1A product tankers and seven VLCCs), 43 are expected to be delivered to the Company in 2014, 16 in 2015 and four in 2016. The Company also owns 30% of Dorian LPG Ltd.Scorpio Tankers, January 29, 2014
The lord chief justice has called on lawyers to take the initiative in shaping their future and not wait for events to shape it for them. Lord Judge said he would be ‘delighted’ if barristers, solicitors and legal executives ‘would together and separately address the structure of the legal profession as the public interest in the administration of justice will require it to be in, shall we say, five years’ time. Maybe even five years is too long’. He told the Institute of Legal Executives’ annual president’s luncheon last week: ‘What I am driving at is the need, first, for the issue to be examined as a whole rather than in isolated compartments, and, second, for the process to be undertaken not as a matter of reaction to events but as a matter of planned construction before the intervention of events. ‘What is needed is foresight… and, perhaps, too, imagination about the world of economic stress and recession and where technological change of extraordinary magnitude will be taking us, and how we should respond to the consequent and inevitable challenges and changes.’ Diane Burleigh, the institute’s chief executive, described the words as ‘spot on’. ‘The public interest requires from lawyers the kind of forward thinking that anticipates new types of legal services delivered in innovative, affordable ways. The public interest demands a bringing together of best business practice with the integrity and respect for the rule of law that is the hallmark of our legal profession.’
Once the chimney is in place, it will be 35 m in height and weigh 100 tonnes.The operation was co-ordinated by Marmedsa Proyectos through Montañesa de Consignaciones, companies belonging to Marmedsa Noatum Maritime.The port boasts two cranes capable of lifting 160 tonnes in tandem and the stevedore describes its terminal as “perfect to carry out such heavy cargo.”Victor Conde, general manager of Noatum Terminal Polivalente Santander, says: “This operation is in line with the strategy of diversification and growth which we have outlined for our multipurpose terminal. Santander Multipurpose Terminal as a model for both global and customised solutions”.Noatum Ports is the largest maritime terminal operator in Spain, with assets in Bilbao, Valencia, Málaga and Las Palmas as well as the largest vehicle handling terminal in the Mediterranean, based in Barcelona. Noatum also operates general cargo terminals in Santander, Sagunto and the intermodal terminal in Madrid.www.noatum.com/en/noatum-ports/santander-terminal-polivalente
The Centre for Justice Innovation has launched its StreetCraft scholarship to encourage innovation by public, private and voluntary sectors working in criminal justice.
Noah Lugo top-scored with 22 markers forthe Cardinals./PN The Blazers was pushed on the brink ofthe elimination with its 7-9 win-loss record.Meanwhile, Mapua University Cardinals stayed on the hunt in Final Four raceafter a 90-73 victory over San Sebastian College Stags. Trailing 41-42 at the half, the RedLions woke up in the third period as Oftana spearheaded the third quarter 27-8scoring run for 72-58 blowout heading into the fourth period. MANILA – San Beda University Red Lionsbroke loose in the second half to maul College of St. Benilde Blazers, 95-73,in the NCAA Season 95 men’s basketball at the San Juan Arena. James Canlas poured in 21 points, nine boards and seven assists. Donald Tankoua got 13 points and five rebounds while Amiel Cris Soberano had 10 points. Justin Gutang tallied 23 points, 16coming from in the first half, alongside five rebounds. “Simplelang ang sinabi ko sa mga players sa halftime. We’re really playing wellin the last 16 games and they will just do the different thing come the 17thgame? Mahiya naman sila sa mga sarilinila,” said Red Lions head coach Boyet Fernandez. The defending champions Red Lions hiked its record to 17-0, one win away from an elimination round sweep and outright finals seat. Calvin Oftana waxed hot in the thirdperiod on Thursday to finish with a career-high 29 points, nine rebounds andfive assists. Calvin Oftana posted a career-high 29 points in San Beda University Red Lions’ victory over the College of St. Benilde Blazers in the NCAA Season 95 men’s basketball on Oct. 10, 2019. TIEBREAKER TIMES PHOTO